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Subject: "University of Florida HSV Research"     Previous Topic | Next Topic
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bella303
Member since Dec-31-08
10 posts
Dec-31-08, 11:20 PM (CST)
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"University of Florida HSV Research"
 
   Hello,

I am an active member of two other Herpes support sites, http://www.herpes-coldsores.com/messageforum/index.php and http://www.yoshi2me.com/phpbb/index.php. There have been discussions about various HSV research that is occurring throughout the research community. In addition, there has been concern about the lack of funding to help the researchers continue their work towards designing a vaccine or cure for HSV.

Since NIH and NAID reserve a small pool of money for HSV each year and since the medical community consider it a non-threatening virus, finding a viable vaccine or cure is not very important. Therefore, the research teams rely on private funding to help sustain their research projects. A few of the projects that we have discussed are the Harvard HSV project, the Duke study, and the University of Florida study.

The Harvard HSV research under the leadership of Dr. Knipe is currently receiving donations and is looking into how to setup an online donation system early 2009. In regards to the Duke HSV research, it might be too early, however, we will inquire about how to donate to the team. One team in particular is the HSV research team from the University of Florida. The U of Fl team is open to receiving donations. However, in order to kick-start the fund to funnel the donations to the researchers and to setup an online donation system on the university's website, they need to receive an initial donation of $2000. The donation can either be from a single source or multiple donors. A donation site to help the U of Fl researchers get started has been setup at http://red-dots-philanthropy.blogspot.com/.

Let's work together to make great things happen.

To learn how it all started, read http://www.herpes-coldsores.com/messageforum/showthread.php?t=14134 and read http://www.herpes-coldsores.com/messageforum/showthread.php?t=14179.


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  Subject     Author     Message Date     ID  
  RE: University of Florida HSV Research muffinadmin Jan-01-09 1
     RE: University of Florida HSV Research bella303 Jan-01-09 2
         RE: University of Florida HSV Research curewillcome Jan-01-09 3
             RE: University of Florida HSV Research bella303 Jan-01-09 4
  Hello, Bella303.. Rajahadmin Jan-01-09 5
     RE: Hello, Bella303.. bella303 Jan-01-09 6
  News from the University of Florida bella303 Jan-09-09 7
     Thanks for the update, Bella. Rajahadmin Jan-09-09 8
         RE: Thanks for the update, Bella. curewillcome Jan-16-09 15
     RE: News from the University of Florida herpesreach Jan-13-09 9
         RE: News from the University of Florida BH Jan-13-09 10
             RE: News from the University of Florida C16679admin Jan-13-09 11
             RE: News from the University of Florida herpesreach Jan-14-09 12
             RE: News from the University of Florida curewillcome Jan-15-09 14
                 RE: News from the University of Florida BH Jan-17-09 18
                     RE: News from the University of Florida curewillcome Jan-18-09 19
     RE: News from the University of Florida muffinadmin Jan-14-09 13
         RE: News from the University of Florida Starla Jan-17-09 16
             RE: News from the University of Florida muffinadmin Jan-17-09 17
                 RE: News from the University of Florida curewillcome Feb-04-09 20
  RE: University of Florida HSV Research bella303 Feb-13-09 21
     Good for you all... Rajahadmin Feb-13-09 22
  RE: University of Florida HSV Research bella303 Apr-17-09 23
     Congratulations, Bella303 Rajahadmin Apr-17-09 24

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muffinadmin
Member since Sep-10-04
6230 posts
Jan-01-09, 10:31 AM (CST)
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1. "RE: University of Florida HSV Research"
In response to message #0
 
LAST EDITED ON Jan-01-09 AT 10:39 AM (CST)
 
It's not clear in the original post but these funds do not go directly to U of FL. They are going to the redspot blog creator who is generating her own marketing campaign on behalf of the U of FL. The intent in that the funds will then be forwarded to U of FL once the initial goal is reached.

Check out the postings in the redspot blog so you have complete information when deciding to contribute.

muffin ~ GHSV1 since 1986

Anyone who has sex is at risk for herpes.

muffin through the years...

>

Paragraphs are a wonderful thing.


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bella303
Member since Dec-31-08
10 posts
Jan-01-09, 05:33 PM (CST)
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2. "RE: University of Florida HSV Research"
In response to message #1
 
   Hello Muffin,

I am the creator of the blog. If I was not clear in the donation blog, I will add clarification so that no one will think that I am trying to pool the funds for myself. To clear my name and the intent of the donation blog, the funds WILL go directly to U of Fl to help them establish an online donation tool. As stated and indicated by my point of contact at U of Fl, in order for the HSV researchers to receive donations via online payment, an initial $2000 needs to be received either by a generous individual donor (if I had the money I would have donated the entire $2000 to help kickstart the fund) or by multiple individuals - the donation blog was started to make it easier for the community to donate. U of Fl does not have a method of collecting the donations for the HSV researchers as they come in. This is my way of supporting the HSV community and to encourage the community that if we come together we can make a difference.

On a much more personal note, I do not need to obtain extra income in a dishonest way. Two degrees, a great career, and a great life have been achieved through hardwork, commitment, and drive.

From what I have read on the message boards, people feel hopeless and helpless. People are given their positive results and a prescription for Valtrex and then sent home without any other information to help them with their diagnosis. The messages that I have read are messages of despair. It saddens me that the HSV community can only give "support". HSV has existed for many many years. Many people have it already and have been living with the virus for many years. Many people are newly diagnosed and what they are fed is the infamous quote of "1 in 5 people have it"..... "it cannot be cured".... "suppressive therapy"...... It troubles me that a community that is strong is numbers have no other recourse but to succumb to the pharmaceuticals by taking their drugs. It troubles me that a virus that is so prevalent is not included in standard STD tests.....

So, for me to sit back and feel hopeless goes against my nature. I do not want to feel hopeless. I do not want to feel beaten by some virus or the pharmaceutical companies.

The HSV community is strong in numbers but yet the voices are faint. Coming together not only means that we want our voices to be heard but that we support each other and we want to make a difference.

This is my way of making a difference.

>It's not clear in the original post but these funds do not
>go directly to U of FL. They are going to the redspot blog
>creator who is generating her own marketing campaign on
>behalf of the U of FL. The intent in that the funds will
>then be forwarded to U of FL once the initial goal is
>reached.
>
>Check out the postings in the redspot blog so you have
>complete information when deciding to contribute.
>
>muffin ~ GHSV1 since 1986
>
>Anyone who has sex is at risk for
>herpes.

>
>muffin through the years...
>
>
>>
>
>Paragraphs are a wonderful thing.


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curewillcome
Member since Dec-22-08
82 posts
Jan-01-09, 06:20 PM (CST)
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3. "RE: University of Florida HSV Research"
In response to message #2
 
   LAST EDITED ON Jan-01-09 AT 06:23 PM (CST)
 
Hi Bella
What a great idea. And I see that the folks at herpes-coldsores.com have done an awesome job collecting funds (is it still $315 to date? http://www.herpes-coldsores.com/messageforum/showthread.php?t=14179&page=7) as well! It's nice to see that some people are actively struggling to make a difference, it really is.
Funds are really tight for me at the moment but when I have a few dollars, I will try and donate, although first I need a PayPal account!


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bella303
Member since Dec-31-08
10 posts
Jan-01-09, 08:01 PM (CST)
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4. "RE: University of Florida HSV Research"
In response to message #3
 
   Hi Curewillcome,

Thank you for your support. Yes, to date $315 have been donated. A member from the herpes-coldsore forum suggested I post on here to get more people involved.....

We CAN make a difference..... Strength in numbers can make a difference.

Thank you again for your support.


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Rajahadmin
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15328 posts
Jan-01-09, 08:34 PM (CST)
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5. "Hello, Bella303.."
In response to message #0
 
LAST EDITED ON Jan-01-09 AT 09:37 PM (CST)
 
Congratulations on being active and getting some contributions flowing toward herpes research.

I've had some experience with trying to get funding to researchers, too, and understand that it has to go through a university foundation or fund raising arm. Usually they will set up an account with the received funds earmarked for specific research projects. I can understand that some universities might require a minimum donation to get an account set up.

I do want to reiterate that our understanding is that the money you are collecting at this stage of the fund raising does not go directly to the University of Florida, but rather that it is held by you, I'm assuming in some sort of escrow account, until you get the required minimum and then it will be remitted to the university.

While this is not something that HHP is directly involved in, I wish you all the best in your efforts and you are welcome to post about it here as it progresses.

"Do the Right Thing. It will gratify some people and astound the rest." - Paraphrased from Mark Twain


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bella303
Member since Dec-31-08
10 posts
Jan-01-09, 10:26 PM (CST)
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6. "RE: Hello, Bella303.."
In response to message #5
 
   LAST EDITED ON Jan-02-09 AT 01:32 AM (CST)
 
Hi Rajah,

My only intent is to make a difference.

Thanks,

Bella303


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bella303
Member since Dec-31-08
10 posts
Jan-09-09, 09:49 AM (CST)
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7. "News from the University of Florida"
In response to message #0
 
   The following is posted at http://www.herpes-coldsores.com/messageforum/showthread.php?p=79671#post79671.

Hi Everyone,

Karen P. (my point of contact) at U of Fl phoned me this morning to give me some information and status on David Bloom's HSV research.

The ribozymes created for HSV1 is ready for clinical trials. When research is at this stage, it is waiting for someone to purchase rights to use it for clinicals. Unless venture capitalists or big pharma purchases the rights, it can sit for years.

The ribozyme study for HSV2 is in pre-clinical study. David Bloom needs funding for this study. There is currently no funding for it. To complete the study it will take $200,000. The good news is that once they complete the study and it is ready for clinical trials, venture capitalists are waiting to purchase the rights to take it to clinical. The venture capitalists are more interested in purchasing the rights for this study because they feel it is more marketable and there will be more interest from the public.

David Bloom is developing a website that will link to his homepage. The website will contain information about both the HSV1 Ribozyme study and HSV2 Ribozyme study. The website will contain a link to allow the people to contribute to the research. He will provide updates on the project and the amount of money raised.

However, we still need to do our part of raising the minimum requirement of $2000 to kickstart the fund. Once the minimum amount is raised, then Karen P. will create the fund that David Bloom can access and use for the research. But David cannot yet receive contributions on his website until we raise the minimum requirement to establish the research fund that is particular for his research.

Karen P. also shared that we are not the only ones who are interested in David Bloom's research. This is most exciting. She was pleased that we have started to raise the funds. I told her we should have the minimum raised by February.

P.S. (a side note) The contribution and contribution letter will be submitted to Karen P.

Thanks,

Bella


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Rajahadmin
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15328 posts
Jan-09-09, 10:18 AM (CST)
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8. "Thanks for the update, Bella."
In response to message #7
 
It looks like you're making good progress.

"Do the Right Thing. It will gratify some people and astound the rest." - Paraphrased from Mark Twain


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curewillcome
Member since Dec-22-08
82 posts
Jan-16-09, 01:37 AM (CST)
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15. "RE: Thanks for the update, Bella."
In response to message #8
 
   Just wanted to share with everyone the fantastic update that the U of Fl fundraising at http://www.herpes-coldsores.com/messageforum/showthread.php?t=14179&page=18 has now reached $1122! Only $878 to go for the start-up fund. Exciting stuff.


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herpesreach
Member since Dec-10-08
4 posts
Jan-13-09, 02:43 PM (CST)
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9. "RE: News from the University of Florida"
In response to message #7
 
   Hello everyone,

I've been looking around for a little while and I'm trying to put together a list of legitimate places that will receive donations regarding herpes research and support.

Duke Study -- ??? (they might not need any money)

UF Study -- http://red-dots-philanthropy.blogspot.com/ (Unofficially Associated with UF)

Harvard Study -- http://knipelab.med.harvard.edu/vaccine.html

ASH -- http://www.ashastd.org/involve/involve_donate_how.cfm

Racoon -- http://racoon.com/fund/

At one time there was a bunch of interest with Bill Halford's research with MSU (now with Southern Illinois University). Anyone have any idea what happened with his work?

Anyone have any other ideas?

Thanks,
HR


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BH
Member since Oct-14-06
4 posts
Jan-13-09, 08:11 PM (CST)
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10. "RE: News from the University of Florida"
In response to message #9
 
   Hi,

A little bird put the word in my ear that someone was asking my research. Thanks for asking.

I approach science as a 2-phase process......1. doing / figuring out how things work (i.e., labwork and bench research) followed by 2. telling other people what I found in the lab (publishing). Since mid-2006, I have been in the lab plus I moved my lab from Montana to Illinois, which slowed me down a bit. Anyway, I am coming out of a 'doing phase,' and am about to enter a 'telling phase.' All I can say is that this next round of 'telling' is going to be a lot of fun.

The work is progressing nicely. Nothing specific I can offer at the moment because I need to publish my results first, and then I can discuss in a public forum after the fact.

What I can generally offer for the moment is the following. The results are highly positive and should open people's eyes about which approaches are, and are not, worth considering to derive an effective genital herpes vaccine. My results suggest that there is a large amount of room for improvement over the herpes vaccines that have been tried in the past.

From my results, I can see the writing on the wall: genital herpes is almost certainly a vaccine-preventable disease provided that individuals are vaccinated before they become sexually active.

I am often asked, "Can a herpes vaccine be used to cure those who already suffer from recurrent gentital herpes?" I would not rule out this possibility, but likewise I would not hold my breath. There are a hundred reasons why the right herpes vaccine (i.e., an effective vaccine) will protect naive people from later exposures to HSV-2. In contrast, there is not a single historical precedent for curing a persistent infection with an "after the fact" vaccine. Again, not impossible, but just a lot less likely.

Once the work is published, and these data are in the public domain, then the challenge will be to wake doctors and other scientists from their slumber of complacency about herpes....just because we failed to cure this in the past is a LAME reason for saying we cannot cure this disease in the future.....Wake up people! Yes, we can in fact prevent tens of millions of people from acquiring HSV-2 every year if, and only if, we get off of our butts and DO SOMETHING as opposed to talking about, maybe, curing herpes one day, if we happen to have some spare time and a few extra dollars in the NIH budget.

The data I have will not address a myriad of concerns that the FDA will have about a new vaccine, nor will the results provide human clinical trial data so there will still be a lot of unknowns to address. However, I think the data will make a compelling case that we (scientists) need to honestly re-evaluate whether or not our past herpes vaccines were really good candidates, learn from our mistakes (rather than trying to hide our mistakes), and then move forward with something that really works.

That's the long version. Short version......yeah, I am still doing herpes research.....look for published results coming to a theater near you (or Pubmed) in 2009.


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C16679admin
Member since Aug-29-06
9733 posts
Jan-13-09, 08:37 PM (CST)
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11. "RE: News from the University of Florida"
In response to message #10
 
   Thanks, Bill, for responding directly!

It's nice to know you're making some good progress. I can't wait to see the published results!

C.


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herpesreach
Member since Dec-10-08
4 posts
Jan-14-09, 02:35 PM (CST)
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12. "RE: News from the University of Florida"
In response to message #10
 
   Very cool. Thank you for taking the time to respond!


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curewillcome
Member since Dec-22-08
82 posts
Jan-15-09, 06:54 AM (CST)
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14. "RE: News from the University of Florida"
In response to message #10
 
   Hi Dr. Halford,

Thanks for taking the time to post. I hope that you come back to take a few questions so I'll put up a few.

So you don't see your research as being able to stop outbreaks and shedding of the virus within those who already have it? Not so much a cure as the virus would still be in your system but enough so that we wouldn't be contagious. I'm sure you know that transmission is often the main concern for both those of us who have it and those who are afraid of catching it. Is that what you're referring to as extremely unlikely or are you talking about rooting the virus out of the system altogether?

Is your work on just HSV-1 or also HSV-2?

I know that your work isn't at the clinical trial stage but what do you think about those that are? Are you optimistic about any of the therapeutic vaccines going into trials at the moment, such as Immunovex and ACAM-529?

Lastly, what is your opinion on the next generation on antivirals, the helicase primase inhibitors -- taken suppressively, are these the permanent suppressive of outbreaks and shedding that we've been waiting for (as we wait for a vaccine)?

Looking forward to reading your research!


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BH
Member since Oct-14-06
4 posts
Jan-17-09, 04:54 PM (CST)
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18. "RE: News from the University of Florida"
In response to message #14
 
   >Hi Dr. Halford,
>
>Thanks for taking the time to post. I hope that you come
>back to take a few questions so I'll put up a few......

>.......Is that what you're referring to as
>extremely unlikely or are you talking about rooting the
>virus out of the system altogether?

As you likely know, people do not get poliomyelitis in the U.S. anymore(crippling disease) thanks to a childhood vaccine (shot) they receive as infants (usually at a pediatrician's office). Likewise, I am talking about developing a childhood vaccine that would protect infants from exposures to HSV-2 later in life. If this succeeds, then one day (30 years from now) the term 'herpes' will seem as obscure and antiquated as the term 'polio' seems today.

>
>Is your work on just HSV-1 or also HSV-2?

Both.

>I know that your work isn't at the clinical trial stage but
>what do you think about those that are? Are you optimistic
>about any of the therapeutic vaccines going into trials at
>the moment, such as Immunovex and ACAM-529?

I will let the data of others speak for itself. It would not be appropriate for me to comment on the merit of herpes vaccines that I have not directly tested in my own research. The only thing I can say is that a promising herpes vaccine has been 'just around the corner' for the last 20 years.....thus, I think it is warranted for everyone to be pessimistic about any putative herpes vaccine (including my own). I live next door to the "Show-me" state, Missouri. I would advise that you adopt a Missouri-like philosophy in your level of optimism towards any scientist who says they have a cure for any disease (i.e., I'll believe the claim if you 'show me the data' that says the claim is true).

>Lastly, what is your opinion on the next generation on
>antivirals, the helicase primase inhibitors -- taken
>suppressively, are these the permanent suppressive of
>outbreaks and shedding that we've been waiting for (as we
>wait for a vaccine)?

I simply do not know enough to give you a meaningful answer. My suspicion is that most new antivirals will be approximately as effective as famcyclovir or pencyclovir (e.g., zovirax) in preventing outbreaks. However, without being familiar with the specifics of the available evidence, I cannot give you a useful answer.

>
>Looking forward to reading your research!

Looking forward to publishing it!

- Bill Halford


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curewillcome
Member since Dec-22-08
82 posts
Jan-18-09, 07:18 AM (CST)
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19. "RE: News from the University of Florida"
In response to message #18
 
   LAST EDITED ON Jan-18-09 AT 07:22 AM (CST)
 
I really appreciate you taking the time, Dr. Halford! Great to hear an informed medical opinion. I'm confident that something better coming soon but at the same time realistic that it won't be here tomorrow! (maybe the day after though )

As for the HPIs, I don't know if you've read this article (http://www.ihmf.org/journal/download/102kleymann(46)vol1046.pdf ) by Dr. Gerald Kleymann of Aicuris on their treatment candidate BAY57-1293 but the results in comparison to valcyclovir seem amazing -- particularly the stats on the charts on pages 50 and 51. Of particular note (to me), was that it suppressed/abrogated shedding nearly completely in murine models and that there were no disease symptoms with twice daily acute treatment. Which bodes really well for transmission, it seems! Plus both Aicuris and Astellas have been extremely secretive so I'm hoping that means something really exciting on their hands to protect their intellectual property! Obviously a vaccine (even with booster shots) would be infinitely superior but from what I've read these will assuage the transmission worries of a lot of people.

Thanks and have a great day.

UPDATE: okay, that link to the BAY57-1293 article just will not work but if you go to this page http://www.ihmf.org/journal/jou_bac.asp and down to Volume 10, issue 2 and find "New Antiviral Drugs that Target Herpesvirus Helicase Primase Enzymes" by Kleymann G then you will find the article that I'm talking about! (Cutting and pasting the link will also work, I believe)


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muffinadmin
Member since Sep-10-04
6230 posts
Jan-14-09, 04:41 PM (CST)
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13. "RE: News from the University of Florida"
In response to message #7
 
Thank you for stopping by, Bill!

muffin ~ GHSV1 since 1986

Anyone who has sex is at risk for herpes.

muffin through the years...

>

Paragraphs are a wonderful thing.


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Starla
Member since Jan-14-09
53 posts
Jan-17-09, 03:57 AM (CST)
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16. "RE: News from the University of Florida"
In response to message #13
 
   What site do I go to I would like to donate


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muffinadmin
Member since Sep-10-04
6230 posts
Jan-17-09, 06:30 AM (CST)
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17. "RE: News from the University of Florida"
In response to message #16
 
If you are interested in supporting the U of Fl the link is in the original post.

muffin ~ GHSV1 since 1986

Anyone who has sex is at risk for herpes.

muffin through the years...

>

Paragraphs are a wonderful thing.


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curewillcome
Member since Dec-22-08
82 posts
Feb-04-09, 08:30 AM (CST)
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20. "RE: News from the University of Florida"
In response to message #17
 
   Just wanted to let you guys know that I have been keeping tabs on this thread over at herpes-coldsores.com and they have raised $1617, with only $383 left to go to reach the target set by the University of Florida! http://www.herpes-coldsores.com/messageforum/showthread.php?t=14179&page=24

I love the idea of this grassroots fund making a real difference.


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bella303
Member since Dec-31-08
10 posts
Feb-13-09, 10:12 PM (CST)
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21. "RE: University of Florida HSV Research"
In response to message #0
 
   All,

The members at www.herpes-coldsores.com have accomplished their first milestone of raising the initial contribution amount to establish a research fund for Dr. David Bloom's HSV Ribozyme Study. The members actually raised over $2000, which is the initial contribution amount required to get the HSV fund started at the University of Florida. We are very excited. We will continue to share updates with you.

Thank you.


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Rajahadmin
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Feb-13-09, 10:32 PM (CST)
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22. "Good for you all..."
In response to message #21
 
Yes, please keep us updated. I made a contribution when it was about 1/2 way there so I'm interested.

"Do the Right Thing. It will gratify some people and astound the rest." - Paraphrased from Mark Twain


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bella303
Member since Dec-31-08
10 posts
Apr-17-09, 08:58 PM (CST)
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23. "RE: University of Florida HSV Research"
In response to message #0
 
   All,

It has been several weeks since I have posted on this board. Our efforts in raising the initial contribution of $2000 for the University of Florida to setup a research fund for the HSV1 and HSV2 Ribozyme study was positive. Thank you for your support and donations.

drum roll please.....

Here are the links to the U of FL HSV1 and HSV2 Research Fund Online Giving.

HSV1 Fund
https://www.uff.ufl.edu/OnlineGiving/FundDetail.asp?FundCode=016081

HSV2 Fund
https://www.uff.ufl.edu/OnlineGiving/FundDetail.asp?FundCode=016087

Congratulations!! It took several weeks and a lot of follow up but here are the links to donate directly to the U of FL HSV1 and HSV2 Research.

Thank you.


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Rajahadmin
Charter Member
15328 posts
Apr-17-09, 09:30 PM (CST)
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24. "Congratulations, Bella303"
In response to message #23
 
My hat's off to you... Thanks for the nice update.

"Do the Right Thing. It will gratify some people and astound the rest." - Paraphrased from Mark Twain


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