The information on the Lectroject website is misleading. They claim that the device is a delivery system for medication. The medication used is acyclovir. Acyclovir is not a cure.
There is no practical way to tell if the virus is still in the body. It hides in the nerve cells, and a blood test can't tell you if it's there or not.
Below is part of the last email I sent them. I wrote this before I saw the report on the components inside the device. After reading that, I don't even think it's safe to try it.
The most important of these assertions are that the use of this device with acyclovir will remove the virus from the body, 100 percent, and that testing before and after with PCR will prove this. Quoting your website:
The medically proven therapy that attacks viral DNA present and totally eliminates it from the body...
When a P.C.R. (Polymerase Cell Response) test, which tracks viral DNA in the body is negative, it means that the virus has been totally eliminated. (100%)
Acyclovir only prevents viral replication, and it only does this while the drug is present in the infected cells. When the acyclovir is gone from the body, which doesn't take very long, the latent viral DNA in the infected neurons is still there and can begin replicating virus particles again. The half-life of acyclovir in the body is about three hours.
If the Lectroject unit can deliver the acyclovir into the body, the best it could possibly be expected to achieve is to stop or to prevent an outbreak, and repeated uses would be required to maintain therapeutic levels of acyclovir in the body.
Whether the device can deliver enough acyclovir to maintain therapeutic levels is another question. The acyclovir concentration in Zovirax ointment is 50mg/g. You state that Lectroject carries the medication to all cells. For comparison, the recommended intravenous dosages of acyclovir range from 5-20mg/kg of body weight over one hour, every eight hours, for a maximum of 60mg/kg/day.(1) A 70kg adult getting the lowest dose of 5mg/kg every eight hours would receive slightly more than a gram of acyclovir in a day, which is comparable to oral doses.
The low concentration of Zovirax ointment is intended to create therapeutic levels of the drug in the local tissues where the ointment is applied. Spreading the drug out through the entire body would require 20 grams of ointment to deliver one gram of acyclovir. That's more than the large size tube of Zovirax ointment (15g.) contains. Your website states that the Lectroject device delivers about 1/1000 of an oral dose of acyclovir. If the acyclovir is going to all cells as you stated, how is such a low dose effective?
Polymerase Chain Reaction (PCR) testing of the blood for Herpes simplex virus will only tell if there is virus in the blood. HSV infection results in latent virus residing inside the nuclei of nerve cells, which are not in contact with the blood. This latency is established within a few hours of inoculation, so we can presume that a positive PCR test for HSV in the blood indicates that there is latent virus in the neurons, but we cannot presume that a negative PCR indicates that latent virus is not present. HSV may appear in the blood during a primary or recurrent episode. A negative PCR will only show that the virus is not replicating at the time the sample was taken.
Most of the studies on PCR testing of blood for HSV have been done with cases of neonatal herpes. In these cases, HSV viremia is not universal - it is found in cases of disseminated herpes, sometimes in cases of herpes encephalitis, and even less commonly in cutaneous infections. I'm only aware of a couple of studies that looked at immunocompetent adults with recurrences. Brice, et. al. found HSV DNA in the peripheral blood of 7 out of 34 subjects during an acute recurrence, and in none a few weeks after lesions healed.(2) Youssef, et. al. found that 7 out of 10 individuals showed virus in the blood during a recurrence, and concluded that "viremia during attacks of recurrent herpes simplex is more frequent than previously appreciated."(3)
Antibody tests for HSV would also be useless for determining whether the virus is gone from the body or not. Specific immune responses are lifelong, so one would expect a positive antibody test, even if there were no virus left in the body. Negative tests following previously positive results could not be assumed to show that the virus was gone. Several authors have shown that HSV antibody tests can give erroneously negative results.(4,5,6) It might also be possible for some antibody levels to fall below detectable levels if there are no recurrences for a long time. I'm not aware that this has been documented with herpes tests, but it is well documented with some of the tests used for EBV.
1. Zovirax prescribing information, from GlaxoSmithKline
2. Brice SL, Stockert SS, Jester JD, Huff JC, Bunker JD, Weston WL. Detection of herpes simplex virus DNA in the peripheral blood during acute recurrent herpes labialis. J Am Acad Dermatol. 1992 Apr;26(4):594-8.
3. Youssef R, Shaker O, Sobeih S, Mashaly H, Mostafa WZ. Detection of herpes simplex virus DNA in serum and oral secretions during acute recurrent herpes labialis. J Dermatol. 2002 Jul;29(7):404-10.
4. Cherpes TL, Ashley RL, Meyn LA, Hillier SL. Longitudinal Reliability of Focus Glycoprotein G-Based Type-Specific Enzyme Immunoassays for Detection of Herpes Simplex Virus Types 1 and 2 in Women. J Clin Microbiol. 2003 February; 41(2): 671–674.
5. Schmid DS, Brown DR, Nisenbaum R, Burke RL, Alexander D, Ashley R, Pellett PE, Reeves WC. Limits in reliability of glycoprotein G-based type-specific serologic assays for herpes simplex virus types 1 and 2. J Clin Microbiol. 1999 Feb;37(2):376-9.
6. Ashley-Morrow R, Krantz E, Wald A. Time course of seroconversion by HerpeSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2. Sex Transm Dis. 2003 Apr;30(4):310-4.