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Subject: "Agenus HerpV (aka AG707) completes Ph 2 study enrollment"     Previous Topic | Next Topic
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Feb-27-13, 05:35 PM (CST)
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"Agenus HerpV (aka AG707) completes Ph 2 study enrollment"

Agenus' HerpV Phase 2 study to treat genital herpes completes enrollment

Agenus announced it has completed patient screening in its Phase 2 randomized, double-blind, multicenter study for HerpV, a recombinant "off-the-shelf" therapeutic vaccine candidate for the treatment of genital herpes in herpes simplex virus-2, or HSV-2, positive patients. HerpV contains Agenus' QS-21 Stimulon adjuvant.

The Phase 2 study has screened over 100 HSV-2 positive subjects and enrollment has been closed. The study will test the biological efficacy of HerpV as measured by effect on genital viral shedding after three injections of the therapeutic vaccine. A booster injection of HerpV will be given at six months after treatment to evaluate the potential durability of treatment effect.

The HerpV Phase 2 study has been supported by leading clinical experts in the field who have expressed that a reduction in viral shedding could translate into clinical benefit. A therapeutic vaccine to treat HSV-2 infected patients has the potential to provide a major paradigm shift in the treatment of this infection as well as provide significant quality of life benefits.

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