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Subject: "summary chart of herpes research" Locked thread - Read only
 
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Conferences Herpes News Topic #794
Reading Topic #794
muffinadmin
Member since Sep-10-04
6230 posts
Mar-13-05, 07:41 AM (CST)
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"summary chart of herpes research"
 
LAST EDITED ON Mar-14-05 AT 07:37 PM (CST)
 
Here's a link to a summary chart which organizes the various herpes treatments and vaccines that are being researched.

www.racoon.com/herpes/chart/

Anything that is highlighted is new information since the last chart posted.

If you discover something new or learn of more recent developments about any of the products on the chart, simply post the information under the Herpes News forum and I will incorporate it into the next version.

The chart is updated periodically on roughly a monthly basis.

muffin

"Everybody hurts sometimes.
So hold on...hold on...hold on...hold on.
Everybody hurts. You're not alone." ~ REM


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  Subject     Author     Message Date     ID  
  RE: summary chart of herpes research Bob Sep-19-05 1
  RE: summary chart of herpes research Bpositive Oct-18-05 2
  RE: summary chart of herpes research Guest Jan-30-06 3
     RE: summary chart of herpes research Hightop Feb-16-06 4
  RE: summary chart of herpes research Anonymous Feb-23-06 5
     RE: summary chart of herpes research muffinadmin Feb-23-06 6
  RE: summary chart of herpes research kac Oct-05-06 7
     RE: summary chart of herpes research Syagrius Mar-05-07 8
  POWDERMED truth Mar-12-07 9
     RE: POWDERMED muffinadmin Mar-13-07 10
         RE: POWDERMED Zarigueya07 Jan-09-08 11
             RE: POWDERMED muffinadmin Jan-10-08 12
  Updated March 8, 2008 Rajahadmin Mar-08-08 13
     RE: Updated March 8, 2008 Weneedacure Mar-13-08 14
         RE: Updated March 8, 2008 muffinadmin Mar-13-08 15
             RE: Updated March 8, 2008 vintage65 Mar-14-08 16
                 Ooops, It should have been a pdf.. Rajahadmin Mar-14-08 19
             RE: Updated March 8, 2008 Weneedacure Mar-14-08 17
                 RE: Updated March 8, 2008 Weneedacure Mar-14-08 18
                     RE: Updated March 8, 2008 vintage65 Mar-14-08 20
                         RE: Updated March 8, 2008/pfizer still developing pmed dna herpes vacc Weneedacure May-08-08 21

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Bob
Guest
Sep-19-05, 08:13 PM (CST)
 
1. "RE: summary chart of herpes research"
In response to message #0
 
   Thank you for your efforts on the chart. It gives hope that at least people are working on a cure.... Thanks again.


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Bpositive
Guest
Oct-18-05, 09:13 PM (CST)
 
2. "RE: summary chart of herpes research"
In response to message #0
 
   Plese keep up the great work!!!


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Guest
Guest
Jan-30-06, 01:55 PM (CST)
 
3. "RE: summary chart of herpes research"
In response to message #0
 
   Muffin, do you know when you will be updating the charts again? I keep praying for miracles like everyone else here has on hoping that they are getting closer with a vaccine or (wishful thinking) cure.

Thank you so much for all your hard work.


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Hightop
Guest
Feb-16-06, 05:58 PM (CST)
 
4. "RE: summary chart of herpes research"
In response to message #3
 
   I just want to thank you for your work on this chart.


Thanks so much. ((HUGS))


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Anonymous
Guest
Feb-23-06, 01:07 PM (CST)
 
5. "RE: summary chart of herpes research"
In response to message #0
 
   Hi Muffin -

Great work on the chart, as usual!

I thought (via our private email) that LipidSciences was going to be added; maybe it will be in the next version, instead?

http://media.corporate-ir.net/media_files/nsd/lipd/CorporatePresentation_11_15_2005.pdf

Check out page 30, there.

Thanks


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muffinadmin
Member since Sep-10-04
6230 posts
Feb-23-06, 06:40 PM (CST)
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6. "RE: summary chart of herpes research"
In response to message #5
 
Anon, I'm sorry about that one. That was an oversight on my part. Raj forwarded the email to me. I simply forgot about it when I was revising the chart. I'll add it in the next version.

I am going to limit the number of broadspectrum antivirals I include on the herpes chart though. There is just too many to track. If someone else it up for the task, please feel free to create a supplemental chart.

muffin

"Everybody hurts sometimes.
So hold on...hold on...hold on...hold on.
Everybody hurts. You're not alone." ~ REM


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kac
Guest
Oct-05-06, 02:46 PM (CST)
 
7. "RE: summary chart of herpes research"
In response to message #0
 
   Didn't know if you were still keeping this updated, but here is a link to an article from the Bayer spinoff company. Sounds as if they are DEFINITELY pursuing BAY 57-1293 (still in pre-clinical phase though). But at least they are doing something. Hope this helps.

http://www.research.bayer.com/medien/pages/2999/herpes.pdf


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Syagrius
Member since Mar-1-07
105 posts
Mar-05-07, 02:59 PM (CST)
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8. "RE: summary chart of herpes research"
In response to message #7
 
   Hi,

It had been a while since this thread has been updated with the latest research news.

To the precedent poster about Bayer's research on BAY 57-1293, I sent them a mail to inform them about another research on University of Florida research on herpes vaccine. Since it is both genetic vaccine, it could rpove interesting to share information.

Syagrius


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truth
Guest
Mar-12-07, 11:08 PM (CST)
 
9. "POWDERMED"
In response to message #0
 
   I recently found an article from April 2005 featuring Lawrence Stanberry (who was the lead investigator for the HSV-2 vaccine trial : NCT00274300.

The article stated " Clinical studies have already demonstrated proof of concept for both prophylactic and therapeutic vaccines for herpes simplex virus (HSV)-2. Both types of HSV-2 vaccines are currently under development and the next few years should bring promising results, accordingto Lawrence R. Stanberry, M.D.,"

The clinical trial mentioned above was on HSV-2 infected victims, which ended on October 2005. However, I noticed there was another trial on HSV-2 seronegative individuals (NCT00310271), which started on April 2006 and is supposed to be completed by April 2007. This trial is mainly to assess safety and tolerability, as well as immunogenicity post vaccination.

It sounds like they already tested the vaccine therapeuticcally and are perhaps are now testing the same vaccine for prevention. However the only time I have seen it mentioned that PowderMed was working on both types was in the article mention above: (http://mommd.mediwire.com/main/Default.aspx?P=Content&ArticleID=157718)

Can anyone shed any light on this? Is it possible that the company might publish all their results after this other trial is completed? (I haven't seen anything recent in the media and only slight mention of the vaccine by Pfizer).

truth


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muffinadmin
Member since Sep-10-04
6230 posts
Mar-13-07, 06:52 PM (CST)
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10. "RE: POWDERMED"
In response to message #9
 
The PowderMed vaccine was going through another Phase I (safety) level trial last year. Since they have been acquired by Pfizer, I believe Pfizer's primary interest is the work PMed did with the flu vaccine. It is unclear at this time whether they will decide to develop the herpes vaccine.

muffin

"Everybody hurts sometimes.
So hold on...hold on...hold on...hold on.
Everybody hurts. You're not alone." ~ REM

http://globalwarmingawareness2007comp.com>


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Zarigueya07
Member since Nov-19-07
28 posts
Jan-09-08, 09:27 PM (CST)
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11. "RE: POWDERMED"
In response to message #10
 
  
Hi there,

Do you think it is woth updating the chart now?
Hope you all have a Great 2008!

Z.


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muffinadmin
Member since Sep-10-04
6230 posts
Jan-10-08, 04:51 PM (CST)
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12. "RE: POWDERMED"
In response to message #11
 
Hi Z,

Rest assured that any developments I have learned about since the summary chart was last released have been posted in the Herpes News section of HHP.

I simply don't have the time right now to devote to updating the chart. If you would like to download the Excel spreadsheet and update it, feel free to submit the revised version to Rajah.

muffin ~ GHSV1 since 1986

muffin through the years...

>

Paragraphs are a wonderful thing.


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Rajahadmin
Charter Member
15328 posts
Mar-08-08, 03:05 PM (CST)
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13. "Updated March 8, 2008"
In response to message #0
 
Thanks again, Muffin, for all the work that went into getting the chart updated.

"Do the Right Thing. It will gratify some people and astound the rest." - Paraphrased from Mark Twain


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Weneedacure
Charter Member
Mar-13-08, 07:50 PM (CST)
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14. "RE: Updated March 8, 2008"
In response to message #13
 
   Muffin or Raj. or anyone else know any info on powdermed's hsv dna vaccine up to date? Pfizer now owns it but do you suppose they will study it further or continue with it in it's current form and progress to a full phase 2 clinical stage? It seems to be the most promising hsv therapeutic vaccine to date? I know they still have an on going phase 1 in study not re-cruiting though? They would be the only therapeutic treatment vaccine available with such significance!! Hopefully pfizer will go forward and not just be concerned with the avian flu dna vaccine!! Also the astella asp2151 compound similar in nature and structure to bay-57 129 is in stage 2 and is still looking for volunteers. That should produce positive info-hopefully!! The powermed web site states that according to there pipeline the hsv dna vaccine is in phase 2a almost phase 2 trials so they done alot so far! The timeline should be much quicker regarding this potential drug! Well thanks for the input-hope all is well for everyone here reading all this info.
Take care-


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muffinadmin
Member since Sep-10-04
6230 posts
Mar-13-08, 08:08 PM (CST)
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15. "RE: Updated March 8, 2008"
In response to message #14
 
I found nothing on the pfizer site about continuing with the PowderMed herpes vaccine. I am not expecting them to continue with it.

I met with Astellas reps at the CDC conference this week. They hope to finish recruiting by July 2008 and to have results of one of the studies by the end of this year.

muffin ~ GHSV1 since 1986

muffin through the years...

>

Paragraphs are a wonderful thing.


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vintage65
Member since Jan-16-08
56 posts
Mar-14-08, 07:57 AM (CST)
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16. "RE: Updated March 8, 2008"
In response to message #15
 
   Hi Muffin;

I tried clicking on the link for the updated chart, but all I get is an Excel spread sheet file.

I'm on a Mac and can't open that. Can you post a .pdf please? Many thanks!


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Rajahadmin
Charter Member
15328 posts
Mar-14-08, 08:43 PM (CST)
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19. "Ooops, It should have been a pdf.."
In response to message #16
 
It's now available either way. You can open .xls spreadsheet files on a Mac if you download and install the free http://OpenOffice.Org office suite, available for almost all operating systems, including OS-X, Linux, Unix and, yes, Windows, too.

"Do the Right Thing. It will gratify some people and astound the rest." - Paraphrased from Mark Twain


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Weneedacure
Charter Member
Mar-14-08, 05:42 PM (CST)
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17. "RE: Updated March 8, 2008"
In response to message #15
 
   Muffin-It's wonderful that this site has you and all the many interested people to give support and help in all the ways you do. The Pfizer site does mention the powdermed infectious diseases vaccines but not specifically the herpes one. More generally speaking. The avian flu vaccine seems to be of much interest for them currently. Does the powdermed vaccine for herpes seem to be promising? The method of dna injection seems promising. Lots of praise in the scientific world on the powderject gun technology. It seems it would be a shame for them not to continue in the clinical phases as they made much progress so far.
On to Astella pharma did you get to ask the reps any specific questions like is it similar in structure to bay-57 129 and how are the results to date regarding the study(it's in phase 2 US. correct?)also in japan. What could we expect as far as limiting out breaks establishing some sort of potential latency from using the drug etc. I did read some where(can't recall)that there were animal studies I believe with the bay 57-129 drug that proved if you took the compound soon after you were exposed to the hsv virus it could basically wipe it out of your system completely or as least get rid of the recurring disease. I may of mis read though? So in closure did you get a lot of good knowledge from the Astella people regarding there
drug? Thanks! Have a great day!!


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Weneedacure
Charter Member
Mar-14-08, 05:54 PM (CST)
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18. "RE: Updated March 8, 2008"
In response to message #17
 
   Oh-forgot to mention this. I read an article that they "Astella-pharma" were trying to get regulators to speed up the time on there investigational drugs such as asp2151 because other drugs were now in generic form and they needed to make up the profit loss with newer drugs in the pipe line etc. Is that realistic that they(FDA) would make such exceptions? Do they ever? Also did astella possibly give any type of time frame if all goes well in the rest of phase 2 and phase 3 is a success time to market? On another note what do you think of Acambis licensing the harvard medical group's dl5-29 herpes vaccine? That could be far off though-but there is a lot of pre-clinical work that has already been done-much indeed! Does that look promising? Well tahnks again.


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vintage65
Member since Jan-16-08
56 posts
Mar-14-08, 09:35 PM (CST)
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20. "RE: Updated March 8, 2008"
In response to message #18
 
   Thanks for the .pdf and link to Excel!


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Weneedacure
Charter Member
May-08-08, 05:14 PM (CST)
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21. "RE: Updated March 8, 2008/pfizer still developing pmed dna herpes vacc"
In response to message #20
 
   RE: Updated March 8, 2008/pfizer still developing pmed dna herpes vaccine?

Just found this out from pfizer's


Our Commitment to Biotherapeutics /
Our Investment in Biotherapeutics

From the front to the back cover of our 2007 annual report, the importance of biotherapeutics to Pfizer is front and center. And the reason is clear. By establishing the biotech culture inside Pfizer, and opening and supporting a growing area of research, we believe we can bring more innovative therapies to patients around the world.

A large part of any investment is action and follow-through. And we are following through by creating a small, agile research unit in Biotherapeutics Research, advancing our biologicals and vaccines portfolios that hold tremendous promise in changing the way diseases are treated — and prevented. We also believe there is tremendous potential in forging new collaborations with scientists around the world and we have a fresh commitment to finding the best science outside our walls.

While we continue to invest and grow our internal capabilities, we will look to invest in relationships with academics, institutions and organizations who can help us advance our cause. As well as building your own partnerships, you will also have access to Pfizer's long standing collaborations, for example, our $100 million collaboration with the Scripps Institute in California.

This work will be backed up with our continued investment strategy. One example of the benefit of this approach is our 2006 acquisition of UK-based PowderMed Ltd. (PowderMed), a pioneer in the particle-mediated epidermal delivery of DNA vaccines. This technology platform may provide significant advantages over both traditional vaccines and “next-wave” cell-based vaccines. PowderMed’s needle-free delivery system uses pressurized helium to place DNA-coated microscopic gold particles into the first layer of skin. This generates both antibody and cell-mediated immune responses. Our researcher supports a belief that eliciting two immune responses, rather than one as in the case of traditional vaccines, will vastly increase vaccine effectiveness. Two influenza vaccines and a genital herpes vaccine are now in our development pipeline as a result of our partnership with our PowderMed colleagues.

Pfizer's chief executive, Jeffrey B. Kindler said in a statement that the move was aimed at “broadening health care solutions for patients” and in all our investments broadening health care solutions will continue to be our aim – whether this is through internal hiring, fostering scientific partnerships or by allowing our scientists access to vital technologies through licensing or acquisitions.

Our dedication to biotherapeutics is strong and unwavering. And we invite you to be a part of our team as move forward and change the world of medicine.

> View Our Positions > Join Our Biotherapeutics Research Network

As this was already in phase 1A/2 development so this could be brought to market in a faster time manner if pfizer does indeed progress the testing of this!! They do list it as in their "pipeline" very good news! Biotherapeutics. I did email them on this and they said they were not at liberty to discuss future developments at this time?

Lets hope for the best!


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