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Subject: "Immunity"     Previous Topic | Next Topic
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Begbie
Member since Mar-6-10
84 posts
Jan-14-12, 00:25 AM (CST)
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"Immunity"
 
   Hi All,

Has anyone heard of someone testing positive to HSV-2 via blood testing (either or both of IGG & IGM) and then having tests taken at a later date (several months or years later) showing up as negative for both (including having multiple follow-up tests from different pathology labs all come back negative)?

My high school biology tells me that if someone has antibodies to a particular condition, that they will have those antibodies for life, giving immunity.

I understand that these tests are testing for antibodies to HSV and that there is probably a certain level of antibodies required to register as a positive. Also I have read that some people who were diagnosed via swabbing and were positive, actually never sero-convert.

Interested to hear anyones thoughts.

Thanks

Unfortunately there aint no such thang as a time machine.


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  Subject     Author     Message Date     ID  
  Yes, false positives happen, but it's rare... Rajahadmin Jan-14-12 1
     RE: Yes, false positives happen, but it's rare... martinlewis Jan-23-12 2
     RE: Yes, false positives happen, but it's rare... martinlewis Jan-23-12 3
     RE: Yes, false positives happen, but it's rare... Begbie Feb-23-12 4
         RE: Yes, false positives happen, but it's rare... CharlesRemo Jul-18-12 5
         RE: Yes, false positives happen, but it's rare... Jadmin Jul-29-12 6

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Rajahadmin
Charter Member
15328 posts
Jan-14-12, 01:07 PM (CST)
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1. "Yes, false positives happen, but it's rare..."
In response to message #0
 
First of all, completely ignore the IgM as it's not at all appropriate for adults since it's cross reactive with other members of the herpes family like Chickenpox and CMV that most adults already have antibodies for. Was the positive result a low number? Did you get a Western Blot as a follow-up?

"Do the Right Thing. It will gratify some people and astound the rest." - Paraphrased from Mark Twain


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martinlewis
Member since Jan-23-12
2 posts
Jan-23-12, 01:31 AM (CST)
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2. "RE: Yes, false positives happen, but it's rare..."
In response to message #1
 
   LAST EDITED ON Jan-23-12 AT 02:00 PM (CDST) by windy (admin)
 
Can anyone describe the actual definition for Immunity?



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martinlewis
Member since Jan-23-12
2 posts
Jan-23-12, 01:33 AM (CST)
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3. "RE: Yes, false positives happen, but it's rare..."
In response to message #1
 
   LAST EDITED ON Jan-23-12 AT 01:34 AM (CDST)
 
>First of all, completely ignore the IgM as it's not at all
>appropriate for adults since it's cross reactive with other
>members of the herpes family like Chickenpox and CMV that
>most adults already have antibodies for. Was the positive
>result a low number? Did you get a Western Blot as a
>follow-up?
>
>"Do the Right Thing. It will gratify some people and
>astound the rest." - Paraphrased from Mark Twain



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Begbie
Member since Mar-6-10
84 posts
Feb-23-12, 05:56 AM (CST)
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4. "RE: Yes, false positives happen, but it's rare..."
In response to message #1
 
   LAST EDITED ON Feb-23-12 AT 05:58 AM (CDST)
 
Hi Rajah,

I did a follow up Western Blot and got my result. It's Negative.
We don't get the numbers over here, just Positive or Negative.
So in the last 9 months I have had 3 serology tests (2 x Igg/Igm, 1 x WB) and in each case negative. Coupled with the fact I have never had the slightest visible symptom, I think I was falsely diagnosed on my initial test where I returned a postitve Igg (negative Igm). In that case the blood sample was taken exactly 1 week after I thought I may have contracted GHSV2 (about 2 years ago). Pretty much everyone on here told me its virtually impossible to sero-convert in that time frame. Also considering the odds of transmission and the fact I only had 'unprotected' sex (broken condom) once with this person (only had sex with this person one time in total)I think I just need to accept the fact that I don't have it and move on. Nothing in life is 100% certain but if I look at all these facts logically, thats the conclusion I draw. Now I just need to get comfortable with it and accept it. Still interested to hear peoples thoughts on this post though.

Ciao

Unfortunately there aint no such thang as a time machine.


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CharlesRemo
Member since Jul-18-12
1 posts
Jul-18-12, 04:58 AM (CST)
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5. "RE: Yes, false positives happen, but it's rare..."
In response to message #4
 
   LAST EDITED ON Jul-19-12 AT 05:40 PM (CDST) by Rajah (admin)
 
Immunity is term that describes a state of having sufficient biological defenses to avoid infection, disease, or other unwanted diseases.It is nothing but the capability of the body to resist harmful microbes from entering the body.

Advertising link removed. Rajah


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Jadmin
Charter Member
1710 posts
Jul-29-12, 08:47 PM (CST)
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6. "RE: Yes, false positives happen, but it's rare..."
In response to message #4
 
   LAST EDITED ON Jul-29-12 AT 08:48 PM (CDST)
 
Hi Begbie:

So basically what you are telling me is that you have had only serology typing done. Do I understand you correctly? Based on population estimates, it is more likely to get a false positive than a false negative. If the only "positive" test result you have is IgM then I would not make anything of it unless you have symptoms indicative of HSV. It really depends on the test and who conducted it -- there is quite a range and really should not be used as a diagnostic, however, it is a simple test that has some reliability and validity (you just have a huge margin of error). If you had a positive culture, then that's a different ball game.

Move forward. However, keep in mind it is highly prevalent and you are at risk even using condoms. Also keep in mind that most cases of genital herpes in individuals under 25 is type 1 (the common cold sore). Also, the Western blot is sensitive to type 2 and rarely detects HSV-1. It is not uncommon to show negative serology results over time. The immune system wanes if a threat disappears, hence why we get re-vacinated. The immune response is a fascinating area and is too complex to address in this post. If you are interested I suggest you look for recent review articles on pubmed.

Good luck,

J


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