Herpesvirus infections - 1

01/27/2001


Click here to start


Table of Contents

Herpesvirus infections - 1

Handouts

Overview

Herpesviruses

Herpesviruses

Herpesviruses

Genetic elements in herpes simplex virus 1.

Herpesviruses

Overview

Varicella-zoster virus (VZV)

Varicella-zoster virus (VZV)

Varicella-zoster virus (VZV)

Herpes simplex viruses: HSV-1 and HSV-2

Herpes simplex viruses: HSV-1 and HSV-2

Overview

HSV life cycle: Primary infection.

1. HSV productive infection (page 3)

1. HSV productive infection (page 3)

HSV life cycle: Establishment of latency.

LAT - ICP0: The ying and yang of HSV latency.

2. Establishment of latency.

Lymphocytes cannot “see” latent viral genomes because no viral antigens

HSV life cycle: reactivation of latent virus.

3. Reactivation of latent HSV. ICP0 triggers reactivation.

HSV life cycle: recurrent disease and viral shedding.

Subclinical HSV reactivation is more the rule than the exception

In summary: HSV goes in....

and HSV comes out…. over and over and over again.

Overview

Varicella-zoster virus (VZV)

Varicella (chickenpox)

Zoster (shingles)

Post-herpetic neuralgia is:

VZV vaccine

Overview

Herpes simplex viruses: seroprevalence versus disease

PPT Slide

Ocular herpes presents as dendritic ulcers.

Diagnosis of HSV disease

Confirming HSV diagnosis

Acyclovir-related antiviral drugs

Acyclovir-related antiviral drugs

Overview

Total number of HSV clinical cases

FACTS

What you should NOT do.

What you should DO.

Information that patients need on 1st visit.

and FINALLY…...

and FINALLY…...

Author: Daniel Joseph Carr, Ph.D.